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Potent anti-coronaviral activity of pateamines and new insights into their mode of action

Pateamines, derived from the sponge Mycale hentscheli, function as inhibitors of the RNA helicase eIF4A and exhibit promising antiviral and anticancer properties. eIF4A plays a pivotal role in unwinding stable RNA structures within the 5′-UTR of selected mRNAs, facilitating the binding of the 43S pr...

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Principais autores: Francesca Magari, Henri Messner, Florian Salisch, Stella M. Schmelzle, Ger van Zandbergen, Alois Fürstner, John Ziebuhr, Andreas Heine, Christin Müller-Ruttloff, Arnold Grünweller
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2024-07-01
Series:Heliyon
Assuntos:
Pateamines
Rocaglates
eIF4A
Antiviral activity
Coronavirus
RNA clamping
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2405844024094404
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