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The Central Role of Glucokinase in Glucose Homeostasis: A Perspective 50 Years After Demonstrating the Presence of the Enzyme in Islets of Langerhans

It is hypothesized that glucokinase (GCK) is the glucose sensor not only for regulation of insulin release by pancreatic β-cells, but also for the rest of the cells that contribute to glucose homeostasis in mammals. This includes other cells in endocrine pancreas (α- and δ-cells), adrenal gland, glu...

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Principais autores: Franz M. Matschinsky, David F. Wilson
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-03-01
coleção:Frontiers in Physiology
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Acesso em linha:https://www.frontiersin.org/article/10.3389/fphys.2019.00148/full
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