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Impaired Myocardial Energetics Causes Mechanical Dysfunction in Decompensated Failing Hearts

Abstract Cardiac mechanical function is supported by ATP hydrolysis, which provides the chemical-free energy to drive the molecular processes underlying cardiac pumping. Physiological rates of myocardial ATP consumption require the heart to resynthesize its entire ATP pool several times per minute....

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Principais autores: Rachel Lopez, Bahador Marzban, Xin Gao, Ellen Lauinger, Françoise Van den Bergh, Steven E Whitesall, Kimber Converso-Baran, Charles F Burant, Daniel E Michele, Daniel A Beard
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2020-01-01
coleção:Function
Assuntos:
heart failure
cardiac energetics
mechanoenergetic coupling
transaortic constriction
ejection fraction
computational modeling
Acesso em linha:https://journals.physiology.org/doi/10.1093/function/zqaa018
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