Prophylactic and therapeutic CSC-based vaccination reduced tumor growth, metastasis and enhanced survival in mouse model of breast cancer

Abstract Background Immunotherapy is a promising cancer treatment, but its effectiveness is limited by the lack of specific strategies to target cancer stem cells (CSCs). CSCs a rare tumor cell subpopulation, are thought to drive tumor recurrence, metastasis, and therapy resistance and developing ta...

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Autores principales:	Masoumeh Dehghan Manshadi, Farideh Hashemi, Sadegh Safaei, Hannaneh Golshahi, Mahmood Bozorgmehr, Leila Eini, Mohammad Reza Bolouri, Zahra Madjd, Roya Ghods
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2026-02-01
Colección:	Breast Cancer Research
Materias:	Cancer stem cells (CSCs) Spheroid formation Vaccine Metastasis Prophylactic vaccination Therapeutic vaccination
Acceso en línea:	https://doi.org/10.1186/s13058-026-02242-7
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