A dual diacylglycerol kinase (DGK) alpha/zeta inhibitor augments the activity of human tumor infiltrating lymphocytes in in vivo and ex vivo models

Endogenous or adoptively transferred tumor-infiltrating lymphocytes (TILs) often lose their functional capacity due to the activation of intrinsic inhibitory pathways, which then limits their ability to control tumor growth. In this study, we examined the effects of blocking a key intracellular inhi...

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מידע ביבליוגרפי

Principais autores:	Phurin Areesawangkit, Karen Pei-Yi Fong, Emma Niemeyer, Yan Li, Kelly Markowitz, Devora Delman, Ryan Krause, Justine Carl, Pat Feldman, Lisa Troung, Rodrigo Hess, Xiaodi Ren, Cynthia Timmers, Sunkyu Kim, Robert Brody, Sunil Singhal, Jarrod Predina, Evgeniy Eruslanov, Gregory Beatty, Bihui Melidosian, Steven M. Albelda
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Taylor & Francis Group 2026-12-01
סדרה:	OncoImmunology
נושאים:	T cells tumor infiltrating lymphocytes T cell hypofunction diacylglycerol kinase diacylglycerol kinase inhibitor tumor digest
גישה מקוונת:	https://www.tandfonline.com/doi/10.1080/2162402X.2025.2608439
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