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Sphingosine-1-Phosphate-Specific G Protein-Coupled Receptors as Novel Therapeutic Targets for Atherosclerosis

Atherosclerosis is a chronic inflammatory process involving complex interactions of modified lipoproteins, monocyte-derived macrophages or foam cells, lymphocytes, endothelial cells (ECs), and vascular smooth muscle cells. Sphingosine-1-phosphate (S1P), a biologically active blood-borne lipid mediat...

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Principais autores: Yoh Takuwa, Kazuaki Yoshioka, Noriko Takuwa, Yasuo Okamoto, Fei Wang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2011-01-01
coleção:Pharmaceuticals
Assuntos:
sphingosine-1-phosphate
S1P1
S1P2
S1P3
atherosclerosis
macrophages
endothelial cells
lymphocytes
Acesso em linha:http://www.mdpi.com/1424-8247/4/1/117/
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