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H&E-based MSI/MMR testing with AI in colorectal cancer: a multi-centred blinded evaluation

Abstract Mismatch repair (MMR) deficiency occurs in 10–20% of colorectal cancer (CRC) cases, leading to microsatellite instability (MSI). Although MSI/MMR testing is critical for CRC management, high costs and long turnaround times limit testing rates and clinical utility, highlighting the need for...

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Автори: Cher Bass, Foivos Ntelemis, Julian Schmidt, Steffen Wolf, André Geraldes, Debapriya Mehrotra, Shikha Singhal, Narender Kumar, Angelica Marcia, Nicholas Bennett, Oscar Maiques, Mitchell Hyde, Bejal Mistry, Grace Rogerson, Michele Cummings, Clare Freer, Elizabeth Walsh, Manuel Salto-Tellez, Maurice Loughrey, In Hwa Um, David J. Harrison, Richard Clarkson, James Blackwood, J. Carl Barrett, Jakob Nikolas Kather, Nicolas M. Orsi, Pahini Pandya, Salim Arslan
Формат: Artigo
Мова:Inglês
Опубліковано: Nature Portfolio 2025-12-01
Серія:npj Digital Medicine
Онлайн доступ:https://doi.org/10.1038/s41746-025-02218-5
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