Dopamine-Mediated Major Depressive Disorder in the Neural Circuit of Ventral Tegmental Area-Nucleus Accumbens-Medial Prefrontal Cortex: From Biological Evidence to Computational Models

Major depressive disorder (MDD) is a serious psychiatric disorder, with an increasing incidence in recent years. The abnormal dopaminergic pathways of the midbrain cortical and limbic system are the key pathological regions of MDD, particularly the ventral tegmental area- nucleus accumbens- medial p...

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Hlavní autoři:	Yuanxi Li, Bing Zhang, Xiaochuan Pan, Yihong Wang, Xuying Xu, Rubin Wang, Zhiqiang Liu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-07-01
Edice:	Frontiers in Cellular Neuroscience
Témata:	major depressive disorder NAc-mPFC-VTA circuit dopamine Hodgkin-Huxley (HH) model dynamical receptor binding model
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fncel.2022.923039/full
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