Somatic estrogen receptor α mutations that induce dimerization promote receptor activity and breast cancer proliferation

Physiologic activation of estrogen receptor α (ERα) is mediated by estradiol (E2) binding in the ligand-binding pocket of the receptor, repositioning helix 12 (H12) to facilitate binding of coactivator proteins in the unoccupied coactivator binding groove. In breast cancer, activation of ERα is ofte...

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Detalhes bibliográficos

Principais autores:	Seema Irani, Wuwei Tan, Qing Li, Weiyi Toy, Catherine Jones, Mayur Gadiya, Antonio Marra, John A. Katzenellenbogen, Kathryn E. Carlson, Benita S. Katzenellenbogen, Mostafa Karimi, Ramya Segu Rajappachetty, Isabella S. Del Priore, Jorge S. Reis-Filho, Yang Shen, Sarat Chandarlapaty
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2024-01-01
coleção:	The Journal of Clinical Investigation
Assuntos:	Endocrinology Oncology
Acesso em linha:	https://doi.org/10.1172/JCI163242
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