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Ablation of the pro-apoptotic protein Bax protects mice from glucocorticoid-induced bone growth impairment.

Dexamethasone (Dexa) is a widely used glucocorticoid to treat inflammatory diseases; however, a multitude of undesired effects have been reported to arise from this treatment including osteoporosis, obesity, and in children decreased longitudinal bone growth. We and others have previously shown that...

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Autors principals: Farasat Zaman, Dionisios Chrysis, Kirsten Huntjens, Bengt Fadeel, Lars Sävendahl
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2012-01-01
Col·lecció:PLoS ONE
Accés en línia:http://europepmc.org/articles/PMC3307731?pdf=render
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