mTOR inhibition promotes ATRA-induced cancer cell differentiation by overcoming a metabolic hyperactive state

Abstract Background All-trans retinoic acid (ATRA), a derivative of vitamin A, potently induces cell maturation in acute promyelocytic leukemia (APL). However, this therapeutic effect is attenuated or absent in non-APL acute myeloid leukemia (AML) and solid tumors. This study aims to elucidate the m...

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Hauptverfasser:	Liuqingqing Zhang, Guiqiyang Xiang, Ping Zhu, Shuting Yu, Fangying Jiang, Shuai Wang, Jinzeng Wang, Yao Dai, Shengyue Wang, Yun Tan, Han Liu, Feng Liu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-05-01
Schriftenreihe:	Journal of Translational Medicine
Schlagworte:	Acute myeloid leukemia All-trans-retinoid acid Single-cell multi-omics Cancer differentiation therapy Metabolism mTOR signaling
Online-Zugang:	https://doi.org/10.1186/s12967-026-08218-7
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