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Sec23a inhibits the self-renewal of melanoma cancer stem cells via inactivation of ER-phagy

Abstract Background The genesis and developments of solid tumors, analogous to the renewal of healthy tissues, are driven by a subpopulation of dedicated stem cells, known as cancer stem cells (CSCs), that exhibit long-term clonal repopulation and self-renewal capacity. CSCs may regulate tumor initi...

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Principais autores: Zhiwei Sun, Doudou Liu, Bin Zeng, Qiting Zhao, Xiaoshuang Li, Hao Chen, Jianyu Wang, H. Rosie Xing
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-03-01
Serier:Cell Communication and Signaling
Fag:
Cancer stem cells
ER-phagy
Sec23a
FAM134B
ER stress
Online adgang:https://doi.org/10.1186/s12964-022-00827-1
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