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Autophagosomes anchor an AKAP11-dependent regulatory checkpoint that shapes neuronal PKA signaling

Abstract Protein Kinase A (PKA) is regulated spatially and temporally via scaffolding of its catalytic (Cα) and regulatory (RI/RII) subunits by the A-kinase-anchoring proteins (AKAP). By binding to an AKAP11 scaffold, PKA engages in poorly understood interactions with autophagy, a key degradation pa...

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Principais autores: Ashley Segura-Roman, Y Rose Citron, Myungsun Shin, Nicole Sindoni, Alex Maya-Romero, Simon Rapp, Claire Goul, Joseph D Mancias, Roberto Zoncu
פורמט: Artigo
שפה:Inglês
יצא לאור: Springer Nature 2025-04-01
סדרה:The EMBO Journal
נושאים:
Protein kinase A
AKAP11
Autophagy
Phosphoproteomics
Signaling
גישה מקוונת:https://doi.org/10.1038/s44318-025-00436-x
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