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Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Copy number variations (CNVs) play a crucial role in cancer diagnostics and prognostics, potentially impacting treatment decisions. Ultra‐low‐pass whole‐genome sequencing (ULP‐WGS) has emerged as a promising alternative to array‐based methods for CNV detection, especially in formalin‐fixed paraffin‐...

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Principais autores: Hanne Goris, Vasiliki Siozopoulou, Léon C vanKempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-05-01
Serier:Molecular Oncology
Fag:
cancer diagnostics
copy number variations
FFPE tissue
SNP array
ULP‐WGS
Online adgang:https://doi.org/10.1002/1878-0261.70192
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