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Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease

Abstract Background Three amino acid differences between rodent and human APP affect medically important features, including β-secretase cleavage of APP and Aβ peptide aggregation (De Strooper et al., EMBO J 14:4932-38, 1995; Ueno et al., Biochemistry 53:7523-30, 2014; Bush, 2003, Trends Neurosci 26...

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Principais autores: Lutgarde Serneels, Dries T’Syen, Laura Perez-Benito, Tom Theys, Matthew G. Holt, Bart De Strooper
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2020-10-01
Serier:Molecular Neurodegeneration
Fag:
Knock-in
Rodent animal models
Alzheimer’s disease
Amyloid-beta precursor protein
Presenilin
Online adgang:http://link.springer.com/article/10.1186/s13024-020-00399-z
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