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Immune Checkpoint FGL1 Expression of Circulating Tumor Cells Is Associated With Poor Survival in Curatively Resected Hepatocellular Carcinoma

LAG-3 is one of the common tumor immune checkpoints. LAG-3 can inhibit the activation and proliferation of T cells, and can also suppress immunity by regulating other immune-related cell functions. FGL1 was recently discovered to be the main ligand of immune checkpoint LAG-3 and play a critical role...

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Principais autores: Qing Yan, Hao-Ming Lin, Ke Zhu, Yi Cao, Xiao-Lin Xu, Zi-Yu Zhou, Lei-bo Xu, Chao Liu, Rui Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-02-01
Serier:Frontiers in Oncology
Fag:
circulating tumor cells
FGL1
hepatocellular carcinoma (HCC)
immunotherapy
clinical application
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2022.810269/full
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