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Anti-MOG autoantibodies pathogenicity in children and macaques demyelinating diseases

Abstract Background Autoantibodies against myelin oligodendrocyte glycoprotein (anti-MOG-Abs) occur in a majority of children with acquired demyelinating syndromes (ADS) and physiopathology is still under investigation. As cynomolgus macaques immunized with rhMOG, all develop an experimental autoimm...

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Hoofdauteurs: Che Serguera, Lev Stimmer, Claire-Maelle Fovet, Philippe Horellou, Vanessa Contreras, Nicolas Tchitchek, Julie Massonneau, Carole Leroy, Audrey Perrin, Julien Flament, Philippe Hantraye, Joanna Demilly, Romain Marignier, Pascale Chrétien, Bert‘t Hart, Jean Boutonnat, Clovis Adam, Roger Le-Grand, Kumaran Deiva
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMC 2019-11-01
Reeks:Journal of Neuroinflammation
Onderwerpen:
Anti-MOG IgG
Cytokines
Complement
Demyelination
Brain inflammation
CSF
Online toegang:https://doi.org/10.1186/s12974-019-1637-7
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