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Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection.

<h4>Background</h4>Human immunodeficiency virus (HIV) infection that persists despite antiretroviral therapy (ART) is a daunting problem. Given the limited evidence that resting CD4+ T cell infection (RCI) is affected by the histone deacetylase (HDAC) inhibitor valproic acid (VPA), we measured the s...

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Principais autores: Nancie M Archin, Manzoor Cheema, Daniel Parker, Ann Wiegand, Ronald J Bosch, John M Coffin, Joseph Eron, Myron Cohen, David M Margolis
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2010-02-01
Serier:PLoS ONE
Online adgang:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0009390&type=printable
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