Apolipoprotein M attenuates age-related macular degeneration phenotypes via sphingosine-1-phosphate signaling and lysosomal lipid catabolism

Abstract Age-related macular degeneration (AMD) is a leading cause of blindness in people over 50. AMD and cardiovascular disease share risk factors including age, impaired lipid metabolism, and extracellular lipid deposition. Because of its importance in age-related diseases, we hypothesize that ap...

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Detalhes bibliográficos

Principais autores:	Tae Jun Lee, Andrea Santeford, Kristen M. Pitts, Carla Valenzuela Ripoll, Ryo Terao, Zhen Guo, Mualla Ozcan, Dagmar Kratky, Christina Christoffersen, Ali Javaheri, Rajendra S. Apte
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-06-01
Colecção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-60830-1
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