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Network medicine modeling of the m⁶A regulatory landscape identifies a KLF6–WTAP axis as a therapeutic target in pulmonary fibrosis

Abstract Background Idiopathic pulmonary fibrosis (IPF) is sustained by multicellular circuits linking endothelial activation, fibroblast remodeling, and immune crosstalk. However, how N⁶-methyladenosine (m⁶A) regulation is embedded within these networks and how such network-level regulators can be...

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Principais autores: Chengyuan Xu, Ziheng Zhou, Yani Lin, Siqi Zhang, Shanshan Cai, Bing Li, Zhifang Wang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-03-01
coleção:Journal of Translational Medicine
Assuntos:
IPF
WTAP
Fibroblast
Single-cell
M⁶A
KLF6
Acesso em linha:https://doi.org/10.1186/s12967-026-07876-x
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