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Translation affects mRNA stability in a codon-dependent manner in human cells

mRNA translation decodes nucleotide into amino acid sequences. However, translation has also been shown to affect mRNA stability depending on codon composition in model organisms, although universality of this mechanism remains unclear. Here, using three independent approaches to measure exogenous a...

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Principais autores: Qiushuang Wu, Santiago Gerardo Medina, Gopal Kushawah, Michelle Lynn DeVore, Luciana A Castellano, Jacqelyn M Hand, Matthew Wright, Ariel Alejandro Bazzini
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2019-04-01
coleção:eLife
Assuntos:
codon optimality
mRNA stability
translation
tRNA
poly(A)-tail
SLAM-seq
Acesso em linha:https://elifesciences.org/articles/45396
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