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Vaccine-Induced Skewing of T Cell Responses Protects Against Chikungunya Virus Disease

Chikungunya virus (CHIKV) infections can cause severe and debilitating joint and muscular pain that can be long lasting. Current CHIKV vaccines under development rely on the generation of neutralizing antibodies for protection; however, the role of T cells in controlling CHIKV infection and disease...

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Principais autores: Rebecca M. Broeckel, Nicole Haese, Takeshi Ando, Igor Dmitriev, Craig N. Kreklywich, John Powers, Michael Denton, Patricia Smith, Thomas E. Morrison, Mark Heise, Victor DeFilippis, Ilhem Messaoudi, David T. Curiel, Daniel N. Streblow
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-10-01
Serier:Frontiers in Immunology
Fag:
Chikungunya virus (CHIKV)
vaccine
T cell
pathogenesis
cytokine
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2019.02563/full
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