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Vericiguat prevents high glucose-mediated impaired vascular smooth muscle cGMP production and vasorelaxation

Abstract Normal endothelial cell dependent vascular smooth muscle cell function is mediated by nitric oxide (NO), which stimulates soluble guanylyl cyclase (sGC) production of the second messenger cyclic guanosine monophosphate (cGMP) leading to increased protein kinase G (PKG) activity and vascular...

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Principais autores: David Polhemus, Diego Almodiel, Tarek Harb, Efthymios Ziogos, Nuria Amat-Codina, Mark Ranek, Lakshmi Santhanam, Gary Gerstenblith, Thorsten M. Leucker
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2025-02-01
coleção:Scientific Reports
Assuntos:
Nitric oxide
cGMP
Vericiguat
Vascular smooth muscle cell function
Protein kinase G activity
Acesso em linha:https://doi.org/10.1038/s41598-025-88938-w
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