Ultra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics

Abstract Distinct platelet activation patterns are elicited by the tyrosine kinase-linked collagen receptor glycoprotein VI (GPVI) and the G-protein coupled protease-activated receptors (PAR1/4) for thrombin. This is reflected in the different platelet Ca2+ responses induced by the GPVI agonist coll...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Delia I. Fernández, Sara Troitiño, Vladimír Sobota, Bibian M. E. Tullemans, Jinmi Zou, Helma van den Hurk, Ángel García, Saman Honarnejad, Marijke J. E. Kuijpers, Johan W. M. Heemskerk
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-03-01
coleção:	Scientific Reports
Assuntos:	Collagen Cytosolic calcium Glycoprotein VI Prestwick library Thrombin Thrombosis
Acesso em linha:	https://doi.org/10.1038/s41598-024-56799-4
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!