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The prognosis of TP53 and EGFR co-mutation in patients with advanced lung adenocarcinoma and intracranial metastasis treated with EGFR-TKIs

BackgroundTP53 mutation is a poor factor for non-small cell lung cancer (NSCLC), while the effect of TP53 on prognosis in epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma (LUAD) with brain metastasis remains elusive and needs further exploration.MethodsWe retrospectively analyzed...

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Principais autores: Weiguo Gu, Penghui Liu, Jiaming Tang, Jianfei Lai, Siya Wang, Jiaming Zhang, Jinbiao Xu, Jianxiong Deng, Feng Yu, Chao Shi, Feng Qiu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-02-01
coleção:Frontiers in Oncology
Assuntos:
lung cancer
brain metastasis
EGFR
TP53
prognosis
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2023.1288468/full
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