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Thyrotropin Regulates eNOS Expression in the Endothelium by PGRN Through Akt Pathway

To investigate the expression of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) in the aorta of subclinical hypothyroidism (SCH) rat model. The mechanisms underlying thyrotropin (TSH) affecting eNOS and PGRN expression in human umbilical vein endothelial cells (HUVECs) cultured in vi...

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Hlavní autoři: Fengwei Jiang, Haoyu Wang, Suqing Bao, Haicheng Zhou, Yuanyuan Zhang, Yumeng Yan, Yaxin Lai, Weiping Teng, Zhongyan Shan
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018-07-01
Edice:Frontiers in Endocrinology
Témata:
subclinical hypothyroidism
thyrotropin
endothelial nitric oxide synthase
progranulin
human umbilical vein endothelial cells
Akt
On-line přístup:https://www.frontiersin.org/article/10.3389/fendo.2018.00353/full
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