Claudin-7 deficiency promotes stemness properties in colorectal cancer through Sox9-mediated Wnt/β-catenin signalling

Abstract Background Colorectal cancer (CRC) is a common malignant tumour of the digestive tract that is characterized by high patient morbidity and mortality rates. Claudin-7 (Cldn7), a tight junction protein, was recently reported to function as a candidate tumour suppressor gene in CRC. Our previo...

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Detalhes bibliográficos

Principais autores:	Chang Xu, Yu-han Ding, Kun Wang, Mengdi Hao, Huimin Li, Lei Ding
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-07-01
coleção:	Journal of Translational Medicine
Assuntos:	Claudin-7 Colorectal cancer Cancer stem cells Epithelial–mesenchymal transition Wnt/β-catenin
Acesso em linha:	https://doi.org/10.1186/s12967-021-02983-3
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