Methotrexate inhibition of SARS-CoV-2 entry, infection and inflammation revealed by bioinformatics approach and a hamster model

BackgroundDrug repurposing is a fast and effective way to develop drugs for an emerging disease such as COVID-19. The main challenges of effective drug repurposing are the discoveries of the right therapeutic targets and the right drugs for combating the disease.MethodsHere, we present a systematic...

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Bibliografische gegevens

Hoofdauteurs:	Yun-Ti Chen, Yu-Hsiu Chang, Nikhil Pathak, Shey-Cherng Tzou, Yong-Chun Luo, Yen-Chao Hsu, Tian-Neng Li, Jung-Yu Lee, Yi-Cyun Chen, Yu-Wei Huang, Hsin-Ju Yang, Nung-Yu Hsu, Hui-Ping Tsai, Tein-Yao Chang, Shu-Chen Hsu, Ping-Cheng Liu, Yuan-Fan Chin, Wen-Chin Lin, Chuen-Mi Yang, Hsueh-Ling Wu, Chia-Ying Lee, Hui-Ling Hsu, Yi-Chun Liu, Jhih-Wei Chu, Lily Hui-Ching Wang, Jann-Yuan Wang, Chih-Heng Huang, Chi-Hung Lin, Po-Shiuan Hsieh, Yan-Hwa Wu Lee, Yi-Jen Hung, Jinn-Moon Yang
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Frontiers Media S.A. 2022-12-01
Reeks:	Frontiers in Immunology
Onderwerpen:	methotrexate SARS-CoV-2 multi-target drugs drug repurposing inflammation
Online toegang:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1080897/full
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