Computer-Driven Development of an in Silico Tool for Finding Selective Histone Deacetylase 1 Inhibitors

Histone deacetylases (HDACs) are a class of epigenetic modulators overexpressed in numerous types of cancers. Consequently, HDAC inhibitors (HDACIs) have emerged as promising antineoplastic agents. Unfortunately, the most developed HDACIs suffer from poor selectivity towards a specific isoform, limi...

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Hlavní autoři:	Hajar Sirous, Giuseppe Campiani, Simone Brogi, Vincenzo Calderone, Giulia Chemi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2020-04-01
Edice:	Molecules
Témata:	3D-QSAR pharmacophore modeling ligand-based model HDACs isoform-selective histone deacetylase inhibitors aminophenylbenzamide
On-line přístup:	https://www.mdpi.com/1420-3049/25/8/1952
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