Data augmentation and multimodal learning for predicting drug response in patient-derived xenografts from gene expressions and histology images

Patient-derived xenografts (PDXs) are an appealing platform for preclinical drug studies. A primary challenge in modeling drug response prediction (DRP) with PDXs and neural networks (NNs) is the limited number of drug response samples. We investigate multimodal neural network (MM-Net) and data augm...

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Principais autores:	Alexander Partin, Thomas Brettin, Yitan Zhu, James M. Dolezal, Sara Kochanny, Alexander T. Pearson, Maulik Shukla, Yvonne A. Evrard, James H. Doroshow, Rick L. Stevens
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2023-03-01
Series:	Frontiers in Medicine
Assuntos:	drug response prediction histology whole-slide images gene expression multimodal deep learning preclinical drug studies data augmentation
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fmed.2023.1058919/full
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