Mitochondrial dysfunction on Leishmania (Leishmania) amazonensis induced by ketoconazole: insights into drug mode of action

BACKGROUND Leishmania parasites cause leishmaniasis that range from self-limiting cutaneous lesions to more serious forms of the disease. The search for potential drug targets focusing on biochemical and metabolic pathways revealed the sterol biosynthesis inhibitors (SBIs) as a promising approach....

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Bibliografski detalji

Glavni autori:	Débora Cristina de Oliveira Silva Nunes, Mônica Soares Costa, Luiz Borges Bispo-da-Silva, Eloísa Amália Vieira Ferro, Mariana Alves Pereira Zóia, Luiz Ricardo Goulart, Renata Santos Rodrigues, Veridiana de Melo Rodrigues, Kelly Aparecida Geraldo Yoneyama
Format:	Artigo
Jezik:	Inglês
Izdano:	Fundação Oswaldo Cruz (FIOCRUZ) 2022-04-01
Serija:	Memorias do Instituto Oswaldo Cruz
Teme:	cutaneous leishmaniasis ergosterol mitochondrial damage sterol biosynthesis inhibitor
Online pristup:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762022000101105&tlng=en
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