PEComa progressed by mTOR inhibitor therapy with anti-VEGFR TKI combined with PD-1 inhibitor: a case report

Malignant perivascular epithelioid cell tumors (PEComas) are rare tumors in which the PI3K/AKT/mTOR pathway is critical for pathogenesis and is often associated with mutations in the TSC1/TSC2 genes. First-line mTOR inhibitors are an effective treatment, but metastatic PEComas eventually develop dru...

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Principais autores:	Guannan Wang, Lili Sun, Jian Guan, Boyan Yang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-09-01
coleção:	Frontiers in Oncology
Assuntos:	malignant perivascular epithelioid cell tumor TSC2 mutation mTOR inhibitor anti-VEGFR TKI PD-1 inhibitor
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1628650/full
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