Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force

Abstract The Notch signaling pathway has fundamental roles in embryonic development and in the nervous system. The current model of receptor activation involves initiation via a force-induced conformational change. Here, we define conditions that reveal pulling force-independent Notch activation usi...

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Principais autores:	Ioanna Smyrlaki, Ferenc Fördős, Iris Rocamonde-Lago, Yang Wang, Boxuan Shen, Antonio Lentini, Vincent C. Luca, Björn Reinius, Ana I. Teixeira, Björn Högberg
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2024-01-01
Serija:	Nature Communications
Online dostop:	https://doi.org/10.1038/s41467-023-44059-4
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