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Donafenib intolerance in hepatocellular carcinoma: severe hand–foot skin reaction and successful switch to lenvatinib – a case report and literature review

BackgroundDonafenib is an approved multikinase inhibitor for hepatocellular carcinoma (HCC). However, cutaneous toxicity—particularly hand–foot skin reaction (HFSR)—may necessitate treatment interruption and compromise therapeutic continuity.Case presentationA 58-year-old man with HCC on a cirrhotic...

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Principais autores: Ying Chen, Linglin Fu, Ping Song, Yinuo Tan, Yuqi Jin
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-12-01
Serier:Frontiers in Oncology
Fag:
donafenib
hepatocellular carcinoma
hand–foot skin reaction
acral toxicity
lenvatinib
tyrosine kinase inhibitor
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2025.1728098/full
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