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Modelling synaptic dysfunction in childhood dementia using human iPSC-derived cortical networks

Abstract Alterations in synaptic homeostasis are linked to cognitive and behavioural impairments in brain disorders. However, synaptic dysfunction in childhood dementia is poorly understood. Here, we generate human cortical circuits from induced pluripotent stem cells (iPSCs) derived from donors wit...

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Principais autores: Paris Mazzachi, Ella McDonald, Zarina Greenberg, Alejandra Noreña Puerta, Jenne Tran, Manam Inushi De Silva, Cade Christensen, Robert Adams, Sebastian Loskarn, Helen Beard, Michael Zabolocki, Meera Elmasri, Megan Maack, Kristina L. Elvidge, Mark R. Hutchinson, Cara O’Neill, Kim M. Hemsley, Lisa Melton, Nicholas Smith, Cedric Bardy
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2026-04-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-026-71112-9
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