Persistent Lipid Accumulation Leads to Persistent Exacerbation of Endoplasmic Reticulum Stress and Inflammation in Progressive NASH via the IRE1α/TRAF2 Complex

Non-alcoholic steatohepatitis (NASH) is a metabolic disorder that often leads to other severe liver diseases, yet treatment options are limited. Endoplasmic reticulum (ER) stress is an important pathogenetic mechanism of NASH and plays a key role in tandem steatosis as well as liver inflammation. Th...

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Bibliografische Detailangaben

Hauptverfasser:	Na Lei, Hongfei Song, Ling Zeng, Shaoxiu Ji, Xiangbo Meng, Xiuying Zhu, Xiuyan Li, Quansheng Feng, Jibin Liu, Jie Mu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2023-04-01
Schriftenreihe:	Molecules
Schlagworte:	non-alcoholic steatohepatitis lipid accumulation endoplasmic reticulum stress IRE1α/TRAF2 complex IKK/IκB/NF-κB signaling pathway ASK1/JNK1 signaling pathway
Online-Zugang:	https://www.mdpi.com/1420-3049/28/7/3185
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