Correction: High Resolution Crystal Structure of Human β-Glucuronidase Reveals Structural Basis of Lysosome Targeting.

Liknande verk

• Correction: High Resolution Crystal Structure of Human β-Glucuronidase Reveals Structural Basis of Lysosome Targeting.
  av: Md Imtaiyaz Hassan, et al.
  Utgiven: (2015-01-01)
• Transgene produces massive overexpression of human β-glucuronidase in mice, lysosomal storage of enzyme, and strain-dependent tumors
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• The overexpressed human 46-kDa mannose 6-phosphate receptor mediates endocytosis and sorting of beta-glucuronidase.
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• STREPTOCOCCAL β-GLUCURONIDASE
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• Active site mutant transgene confers tolerance to human β-glucuronidase without affecting the phenotype of MPS VII mice
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