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Glesatinib, a c-MET/SMO Dual Inhibitor, Antagonizes P-glycoprotein Mediated Multidrug Resistance in Cancer Cells

Multidrug resistance (MDR) is one of the leading causes of treatment failure in cancer chemotherapy. One major mechanism of MDR is the overexpressing of ABC transporters, whose inhibitors hold promising potential in antagonizing MDR. Glesatinib is a dual inhibitor of c-Met and SMO that is under phas...

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Principais autores: Qingbin Cui, Chao-Yun Cai, Hai-Ling Gao, Liang Ren, Ning Ji, Pranav Gupta, Yuqi Yang, Suneet Shukla, Suresh V. Ambudkar, Dong-Hua Yang, Zhe-Sheng Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-04-01
coleção:Frontiers in Oncology
Assuntos:
multidrug resistance
P-gp
glesatinib
reversal effects
mechanism
Acesso em linha:https://www.frontiersin.org/article/10.3389/fonc.2019.00313/full
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