Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation

Abstract Background Pulmonary inflammation in response to respiratory infections can evoke muscle wasting. Increased activity of the ubiquitin (Ub)-proteasome system (UPS) and the autophagy lysosome pathway (ALP) have been implicated in inflammation-induced muscle atrophy. Since poly-Ub conjugation...

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Detalhes bibliográficos

Principais autores:	Judith J. M. Ceelen, Annemie M. W. J. Schols, Nathalie G. M. Thielen, Astrid Haegens, Douglas A. Gray, Marco C. J. M. Kelders, Chiel C. de Theije, Ramon C. J. Langen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-05-01
coleção:	Respiratory Research
Assuntos:	Inflammation Skeletal muscle atrophy Autophagy Poly-ubiquitin Proteolysis Protein synthesis
Acesso em linha:	http://link.springer.com/article/10.1186/s12931-018-0753-8
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