Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects

Abstract Background Bones have a remarkable capacity to heal upon fracture. Yet, in large defects or compromised conditions healing processes become impaired, resulting in delayed or non-union. Current therapeutic approaches often utilize autologous or allogeneic bone grafts for bone augmentation. H...

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Detalhes bibliográficos

Principais autores:	Wai Long Tam, Luís Freitas Mendes, Xike Chen, Raphaëlle Lesage, Inge Van Hoven, Elke Leysen, Greet Kerckhofs, Kathleen Bosmans, Yoke Chin Chai, Akihiro Yamashita, Noriyuki Tsumaki, Liesbet Geris, Scott J. Roberts, Frank P. Luyten
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-09-01
coleção:	Stem Cell Research & Therapy
Assuntos:	Stem cell technology Organoid biology Bone tissue engineering Induced pluripotent stem cells Endochondral ossification Cartilage
Acesso em linha:	https://doi.org/10.1186/s13287-021-02580-7
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