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Combinatorial Loss of the Enzymatic Activities of Viral Uracil-DNA Glycosylase and Viral dUTPase Impairs Murine Gammaherpesvirus Pathogenesis and Leads to Increased Recombination-Based Deletion in the Viral Genome

ABSTRACT Misincorporation of uracil or spontaneous cytidine deamination is a common mutagenic insult to DNA. Herpesviruses encode a viral uracil-DNA glycosylase (vUNG) and a viral dUTPase (vDUT), each with enzymatic and nonenzymatic functions. However, the coordinated roles of these enzymatic activi...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Qiwen Dong, Kyle R. Smith, Darby G. Oldenburg, Maxwell Shapiro, William R. Schutt, Laraib Malik, Joshua B. Plummer, Yunxiang Mu, Thomas MacCarthy, Douglas W. White, Kevin M. McBride, Laurie T. Krug
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018-11-01
Schriftenreihe:mBio
Schlagworte:
DNA replication
dUTPase
gammaherpesvirus
genomic stability
herpesviruses
latency
Online-Zugang:https://journals.asm.org/doi/10.1128/mBio.01831-18
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