Mycobactin analogue interacting with siderophore efflux-pump protein: insights from molecular dynamics simulations and whole-cell assays

IntroductionIn response to continued public health emergency of antimicrobial resistance (AMR), a significant key strategy is the discovery of novel mycobacterial efflux-pump inhibitors (EPIs) as potential adjuvants in combination drug therapy. Interest in identifying new chemotypes which could pote...

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Autors principals:	Mousumi Shyam, Abhishek Thakur, Caroline Velez, Chris Daniel, Orlando Acevedo, Sanjib Bhakta, Venkatesan Jayaprakash
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2024-05-01
Col·lecció:	Frontiers in Antibiotics
Matèries:	mycobactin analogues efflux-pump MmpL4 MmpL5 efflux-pump inhibitors homology modelling molecular docking
Accés en línia:	https://www.frontiersin.org/articles/10.3389/frabi.2024.1362516/full
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