Complete deconvolution of cellular mixtures based on linearity of transcriptional signatures
Complete gene expression deconvolution remains a challenging problem. Here, the authors provide a solution based on the recognition that expression levels of cell type specific genes are mutually linear across mixtures and mutually linear gene clusters correspond to cell type-specific signatures.
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2019-05-01
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| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-019-09990-5 |
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