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Influence of a GSK3β phosphorylation site within the proximal C-terminus of Neurofilament-H on neurofilament dynamics

Phosphorylation of the C-terminal tail of the heavy neurofilament subunit (NF-H) impacts neurofilament (NF) axonal transport and residence within axons by fostering NF-NF associations that compete with transport. We tested the role of phosphorylation of a GSK-3β consensus site (S493) located in the...

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Principais autores: Rishel Brenna Vohnoutka, Edward F. Boumil, Yuguan Liu, Atsuko Uchida, Harish C. Pant, Thomas B. Shea
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2017-10-01
coleção:Biology Open
Assuntos:
Axonal cytoskeleton
Neurofilament
Phosphorylation
Protein conformation
Proteolysis
Acesso em linha:http://bio.biologists.org/content/6/10/1516
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