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Structure–Activity Relationship Studies of Tetracyclic Pyrrolocarbazoles Inhibiting Heterotetrameric Protein Kinase CK2

The serine/threonine kinase CK2 (formerly known as casein kinase II) plays a crucial role in various CNS disorders and is highly expressed in various types of cancer. Therefore, inhibiting this key kinase could be promising for the treatment of these diseases. The CK2 holoenzyme is formed by the rec...

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Autori principali: Lukas Kröger, Sebastian Borgert, Miriam Lauwers, Michaela Steinkrüger, Joachim Jose, Markus Pietsch, Bernhard Wünsch
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2024-12-01
Serie:Molecules
Soggetti:
CK2
protein kinase
heterotetrameric enzyme
protein–protein interaction
enzyme inhibition
Levy reaction
Accesso online:https://www.mdpi.com/1420-3049/30/1/63
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