Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein

During diabetes, postprandial hyperglycemia is caused by impaired glucose uptake. Here, Watanabe and colleagues show that impaired hepatic glucose uptake during obesity is caused by a reduction in Sirt2 activity, which promotes glucokinase regulatory protein acetylation and its dissociation from glu...

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Autors principals:	Hitoshi Watanabe, Yuka Inaba, Kumi Kimura, Michihiro Matsumoto, Shuichi Kaneko, Masato Kasuga, Hiroshi Inoue
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2018-01-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-017-02537-6
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