Human pluripotent reprogramming with CRISPR activators

CRISPRa is an attractive tool for cellular reprogramming due to its multiplexing capacity and direct targeting of genomic loci. Here the authors demonstrate the reprogramming of human fibroblasts into iPSCs, which is enhanced by targeting a conserved Alu-motif.

書誌詳細

主要な著者:	Jere Weltner, Diego Balboa, Shintaro Katayama, Maxim Bespalov, Kaarel Krjutškov, Eeva-Mari Jouhilahti, Ras Trokovic, Juha Kere, Timo Otonkoski
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2018-07-01
シリーズ:	Nature Communications
オンライン･アクセス:	https://doi.org/10.1038/s41467-018-05067-x
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