The role of exosomes as oligonucleotide delivery system for managing α-synuclein in Parkinson’s disease: A systematic review of in vivo studies

Although Parkinson’s disease (PD) is primarily idiopathic, genetic mutations—accounting for approximately 5%–15% of cases with regional variability—have prompted the development of gene expression modulators, such as oligonucleotides, to target and reduce alpha-synuclein (α-syn) accumulation. Howeve...

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Autors principals:	Soodeh Salarpour, Fatemeh Dourandish, Arsalan Salajegheh, Sara Hashemi
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-12-01
Col·lecció:	Molecular Therapy: Nucleic Acids
Matèries:	MT Oligonucleotides Therapies and Applications exosome oligonucleotide delivery alpha-synuclein
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2162253125003300
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