Modified Shen-Yan-Fang-Shuai formula attenuates diabetic kidney disease progression via regulation of HIF-1α-mediated mitochondrial energy metabolism

Abstract Background Diabetic kidney disease (DKD) represents a major global health burden, affecting 20–40% of diabetic patients worldwide. Metabolic reprogramming mediated by hypoxia-inducible factor-1α (HIF-1α) plays a central role in DKD pathogenesis, yet effective therapeutic strategies remain l...

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Detalhes bibliográficos

Principais autores:	Bingnan Di, Yaotan Li, Jinyan Wei, Yizhen Han, Jinyi Hou, Xinghua Zhang, Xiaochang Wu, Weijing Liu, Huijuan Zheng, Yaoxian Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-01-01
coleção:	Chinese Medicine
Assuntos:	Diabetic kidney disease HIF-1α Metabolic reprogramming Mitochondrial dysfunction Traditional Chinese medicine Glycolysis
Acesso em linha:	https://doi.org/10.1186/s13020-025-01298-5
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