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<i>In Vitro</i> Interaction of Binuclear Copper Complexes with Liver Drug-Metabolizing Cytochromes P450

Two copper(II) mixed ligand complexes with dicarboxylate bridges were prepared and studied, namely [Cu<sub>2</sub>(μ-fu)(pmdien)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](ClO<sub>4</sub>)<sub>2</sub> (complex No. 5) and [Cu<sub>2</sub>(μ-dtdp)(pmdien)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](ClO<sub>...

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Principais autores: Alena Špičáková, Zuzana Horáčková, Pavel Kopel, Pavel Anzenbacher
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-09-01
Serier:Pharmaceuticals
Fag:
cytochromes P450
enzyme activity
inhibition
drug interactions
copper complexes
dicarboxylic acid
Online adgang:https://www.mdpi.com/1424-8247/17/9/1194
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